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KMID : 1002120050020020007
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Journal of Korean Sleep Research Society
2005 Volume.2 No. 2 p.7 ~ p.12
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Restless legs syndrome : Pathophysiology and Treatment
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Han Hyun-Jeong
Kim Hye-Yun
Shin Dong-Ick
Ku Bon-D.
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Abstract
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The restless legs syndrome (RLS) is common sensorimotor disorder with a prevalence of about 5 to 10% in the general population, but only recently become recognized as a significant clinical and pathophysiologic problem. Despite intensive research the pathophysiological mechanism underlying RLS have remained obscure. In general, RLS encompasses an idiopathic form of genetic or unknown origin and symptomatic forms associated with uremia, iron depletion, polyneuropathy, spinal disorder and rheumatoid arthritis. Pathophysiology and treatment may be closed linked to the dopaminergic system and iron metabolism. Dopaminergic treatment with levodopa and dopamine agonist is the first choice in idiopathic restless legs syndome, but augmentation should be monitored in long-term treatment. Various other drugs, such as opioids, gabapentin, and benzodiazepines and iron, provided alternative treatment possibilities. The authors reviewed recent advances in the pathophysiologic mechanism and treatment modalities of the RLS.
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KEYWORD
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Restless legs syndrome, Pathophysiology, Treatment
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